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The environmental impact of ivermectin use, particularly in agriculture and aquaculture, has raised concerns about its potential effects on non-target organisms and ecosystems. Residues of the drug may persist in soil, water, and sediment, posing risks to aquatic and terrestrial organisms through direct toxicity or bioaccumulation in the food chain. Strategies to mitigate environmental contamination include improved drug formulations, optimized dosing regimens, and wastewater treatment technologies to minimize the release of active ingredients into the environment.

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